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Flexible substrata for the detection of cellular traction forcesBy modulating adhesion signaling and cytoskeletal organization, mechanical forces play an important role in various cellular functions, from propelling cell migration to mediating communication between cells. Recent developments have resulted in several new approaches for the detection, analysis and visualization of mechanical forces generated by cultured cells. Combining these methods with other approaches, such as green-fluorescent protein (GFP) imaging and gene manipulation, proves to be particularly powerful for analyzing the interplay between extracellular physical forces and intracellular chemical events.
Document ID
20040088460
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Beningo, Karen A.
(University of Massachusetts Medical School 377 Plantation Street, Worcester, MA 01605, United States)
Wang, Yu-Li
Date Acquired
August 21, 2013
Publication Date
February 1, 2002
Publication Information
Publication: Trends in cell biology
Volume: 12
Issue: 2
ISSN: 0962-8924
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: GM-32476
CONTRACT_GRANT: GM-20578
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Review
Non-NASA Center
NASA Discipline Cell Biology

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