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Skeletal adaptation to external loads optimizes mechanical properties: fact or fictionThe skeleton adapts to a changing mechanical environment but the widely held concept that bone cells are programmed to respond to local mechanical loads to produce an optimal mechanical structure is not consistent with the high frequency of bone fractures. Instead, the author suggests that other important functions of bone compete with mechanical adaptation to determine structure. As a consequence of competing demands, bone architecture never achieves an optimal mechanical structure. c2001 Lippincott Williams & Wilkins, Inc.
Document ID
20040088461
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Turner, R. T.
(Mayo Clinic Rochester, MN 55905, United States)
Date Acquired
August 21, 2013
Publication Date
October 1, 2001
Publication Information
Publication: Current opinion in orthopaedics
Volume: 12
Issue: 5
ISSN: 1041-9918
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NCC9-58
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Discipline Cell Biology
Non-NASA Center
Review

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