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Spectroscopic detection of biological NO with a quantum cascade laserTwo configurations of a continuous wave quantum cascade distributed feedback laser-based gas sensor for the detection of NO at a parts per billion (ppb) concentration level, typical of biomedical applications, have been investigated. The laser was operated at liquid nitrogen temperature near lambda = 5.2 microns. In the first configuration, a 100 m optical path length multi-pass cell was employed to enhance the NO absorption. In the second configuration, a technique based on cavity-enhanced spectroscopy (CES) was utilized, with an effective path length of 670 m. Both sensors enabled simultaneous analysis of NO and CO2 concentrations in exhaled air. The minimum detectable NO concentration was found to be 3 ppb with a multi-pass cell and 16 ppb when using CES. The two techniques are compared, and potential future developments are discussed.
Document ID
20040088505
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Menzel, L.
(Rice Quantum Institute, Rice University Houston, TX 77251-1892, United States)
Kosterev, A. A.
Curl, R. F.
Tittel, F. K.
Gmachl, C.
Capasso, F.
Sivco, D. L.
Baillargeon, J. N.
Hutchinson, A. L.
Cho, A. Y.
Urban, W.
Date Acquired
August 21, 2013
Publication Date
May 1, 2001
Publication Information
Publication: Applied physics. B, Lasers and optics
Volume: 72
Issue: 7
ISSN: 0946-2171
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Environmental Health
Non-NASA Center

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