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Obstructive apnea during sleep is associated with peripheral vasoconstrictionObstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 +/- 8% from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.
Document ID
20040088531
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Imadojemu, Virginia A.
(Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine Hershey, Pennsylvania 17033, United States)
Gleeson, Kevin
Gray, Kristen S.
Sinoway, Lawrence I.
Leuenberger, Urs A.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: American journal of respiratory and critical care medicine
Volume: 165
Issue: 1
ISSN: 1073-449X
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: K24 HL04011
CONTRACT_GRANT: K23 HL04190
CONTRACT_GRANT: M01 RR10732
CONTRACT_GRANT: R01 AG12227
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

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