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Calcium metabolism and cardiovascular function after spaceflightTo determine the influence of dietary calcium on spaceflight-induced alterations in calcium metabolism and blood pressure (BP), 9-wk-old spontaneously hypertensive rats, fed either high- (2%) or low-calcium (0.02%) diets, were flown on an 18-day shuttle flight. On landing, flight animals had increased ionized calcium (P < 0.001), elevated parathyroid hormone levels (P < 0.001), reduced calcitonin levels (P < 0.05), unchanged 1,25(OH)(2)D(3) levels, and elevated skull (P < 0.01) and reduced femur bone mineral density. Basal and thrombin-stimulated platelet free calcium (intracellular calcium concentration) were also reduced (P < 0.05). There was a tendency for indirect systolic BP to be reduced in conscious flight animals (P = 0.057). However, mean arterial pressure was elevated (P < 0.001) after anesthesia. Dietary calcium altered all aspects of calcium metabolism (P < 0.001), as well as BP (P < 0.001), but the only interaction with flight was a relatively greater increase in ionized calcium in flight animals fed low- compared with high-calcium diets (P < 0.05). The results indicate that 1) flight-induced disruptions of calcium metabolism are relatively impervious to dietary calcium in the short term, 2) increased ionized calcium did not normalize low-calcium-induced elevations of BP, and 3) parathyroid hormone was paradoxically increased in the high-calcium-fed flight animals after landing.
Document ID
20040088606
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hatton, Daniel C.
(Oregon Health Sciences University Portland, Oregon 97201, United States)
Yue, Qi
Dierickx, Jacqueline
Roullet, Chantal
Otsuka, Keiichi
Watanabe, Mitsuaki
Coste, Sarah
Roullet, Jean Baptiste
Phanouvang, Thongchan
Orwoll, Eric
Orwoll, Shiela
McCarron, David A.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 92
Issue: 1
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center
short duration
NASA Experiment Number 9401686
manned
STS-80 Shuttle Project
Flight Experiment

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