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Animal models for osteoporosisAnimal models will continue to be important tools in the quest to understand the contribution of specific genes to establishment of peak bone mass and optimal bone architecture, as well as the genetic basis for a predisposition toward accelerated bone loss in the presence of co-morbidity factors such as estrogen deficiency. Existing animal models will continue to be useful for modeling changes in bone metabolism and architecture induced by well-defined local and systemic factors. However, there is a critical unfulfilled need to develop and validate better animal models to allow fruitful investigation of the interaction of the multitude of factors which precipitate senile osteoporosis. Well characterized and validated animal models that can be recommended for investigation of the etiology, prevention and treatment of several forms of osteoporosis have been listed in Table 1. Also listed are models which are provisionally recommended. These latter models have potential but are inadequately characterized, deviate significantly from the human response, require careful choice of strain or age, or are not practical for most investigators to adopt. It cannot be stressed strongly enough that the enormous potential of laboratory animals as models for osteoporosis can only be realized if great care is taken in the choice of an appropriate species, age, experimental design, and measurements. Poor choices will results in misinterpretation of results which ultimately can bring harm to patients who suffer from osteoporosis by delaying advancement of knowledge.
Document ID
20040088665
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Turner, R. T.
(Mayo Clinic 200 First Street SW, Rochester, MN 55905, United States)
Maran, A.
Lotinun, S.
Hefferan, T.
Evans, G. L.
Zhang, M.
Sibonga, J. D.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Reviews in endocrine & metabolic disorders
Volume: 2
Issue: 1
ISSN: 1389-9155
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR45233
CONTRACT_GRANT: AA11140
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Review, Tutorial
Review
Non-NASA Center

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