NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Chronic mitral regurgitation and Doppler estimation of left ventricular filling pressures in patients with heart failurePrevious studies relating Doppler parameters and pulmonary capillary wedge pressures (PCWP) typically exclude patients with severe mitral regurgitation (MR). We evaluated the effects of varying degrees of chronic MR on the Doppler estimation of PCWP. PCWP and mitral Doppler profiles were obtained in 88 patients (mean age 55 +/- 8 years) with severe left ventricular (LV) dysfunction (mean ejection fraction 23% +/- 5%). Patients were classified by severity of MR. Patients with severe MR had greater left atrial areas, LV end-diastolic volumes, and mean PCWPs and lower ejection fractions (each P <.01). In patients with mild MR, multiple echocardiographic parameters correlated with PCWP; however, with worsening MR, only deceleration time strongly related to PCWP. From stepwise multivariate analysis, deceleration time was the best independent predictor of PCWP overall, and it was the only predictor in patients with moderate or severe MR. Doppler-derived early mitral deceleration time reliably predicts PCWP in patients with severe LV dysfunction irrespective of degree of MR.
Document ID
20040088671
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Temporelli, P. L.
(Medical Center of Rehabilitation Via Revislate, 13, 28010 Veruno (NO), Italy)
Scapellato, F.
Corra, U.
Eleuteri, E.
Firstenberg, M. S.
Thomas, J. D.
Giannuzzi, P.
Date Acquired
August 21, 2013
Publication Date
November 1, 2001
Publication Information
Publication: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Volume: 14
Issue: 11
ISSN: 0894-7317
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 1R01 HL 56688-01A1
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available