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System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptorsProlonged exposure to microgravity in space flight missions (days) impairs the mechanisms responsible for defense of arterial blood pressure (ABP) and cardiac output (CO) against orthostatic stress in the post-flight period. The mechanisms responsible for the observed orthostatic intolerance are not yet completely understood. Additionally, effective counter measures to attenuate this pathophysiological response are not available. The aim of this study was to investigate the ability of our proposed system identification method to predict closed-loop dynamic changes in TPR induced by changes in mean arterial pressure (MAP) and right atrial pressure (RAP). For this purpose we designed and employed a novel experimental animal model for the examination of arterial and cardiopulmonary baroreceptors in the dynamic closed-loop control of total peripheral resistance (TPR), and applied system identification to the analysis of beat-to-beat fluctuations in the measured signals. Grant numbers: NAG5-4989. c 2001. Elsevier Science Ltd. All rights reserved.
Document ID
20040088703
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Aljuri, A. N.
(NASA Headquarters Washington, DC United States)
Bursac, N.
Marini, R.
Cohen, R. J.
Date Acquired
August 21, 2013
Publication Date
August 1, 2001
Publication Information
Publication: Acta astronautica
Volume: 49
Issue: 3-10
ISSN: 0094-5765
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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