Record Details

The risk of renal stone formation during and after long duration space flight
External Online Source: doi:10.1159/000046083
Author and Affiliation:
Whitson, P. A.(NASA Johnson Space Center, Houston TX United States);
Pietrzyk, R. A.
Morukov, B. V.
Sams, C. F.
Abstract: BACKGROUND: The formation of a renal stone during space flight may have serious negative effects on the health of the crewmember and the success of the mission. Urinary biochemical factors and the influence of dietary factors associated with renal stone development were assessed during long duration Mir Space Station missions. METHODS: Twenty-four-hour urine samples were collected prior to, during and following long duration space flight. The relative urinary supersaturation of calcium oxalate, calcium phosphate (brushite), sodium urate, struvite and uric acid were determined. RESULTS: Changes in the urinary biochemistry of crewmembers during long duration spaceflight demonstrated increases in the supersaturation of the stone-forming salts. In-flight hypercalciuria was evident in a number of individual crewmembers and 24-hour dietary fluid intake and urine volume were significantly lower. During flight, there was a significant increase in brushite supersaturation. CONCLUSIONS: These data suggest acute effects of space flight and postflight changes in the urinary biochemistry favoring increased crystallization in the urine. The effects of dietary intake, especially fluid intake, may have a significant impact on the potential for renal stone formation. Efforts are now underway to assess the efficacy of a countermeasure to mitigate the increased risk. Copyright 2001 S. Karger AG, Basel.
Publication Date: Nov 01, 2001
Document ID:
20040088732
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Nephron (ISSN 0028-2766); Volume 89; 3; 264-70
Publisher Information: Switzerland
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ETIOLOGY; KIDNEY STONES; LONG DURATION SPACE FLIGHT; RISK; WEIGHTLESSNESS; ADULTS; CALCIUM COMPOUNDS; CALCIUM PHOSPHATES; CITRATES; DIETS; MIR SPACE STATION; NUTRITIONAL REQUIREMENTS; TIME DEPENDENCE; URINE
Other Descriptors: KIDNEY CALCULI/ETIOLOGY/PREVENTION & CONTROL; SPACE FLIGHT; WEIGHTLESSNESS; ADULT; CALCIUM OXALATE/URINE; CALCIUM PHOSPHATES/URINE; CITRATES/URINE; DIET; HUMAN; MIDDLE AGED; NUTRITIONAL REQUIREMENTS; RISK FACTORS; SUPPORT, U.S. GOV'T, NON-P.H.S; TIME FACTORS; URINE; FLIGHT EXPERIMENT; MIR PROJECT; LONG DURATION; MANNED; NASA CENTER JSC; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NASA EXPERIMENT NUMBER 9401651
Availability Source: Other Sources
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