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Phase sensitive x-ray diffraction imaging of defects in biological macromolecular crystalsConventional x-ray diffraction topography is currently used to map defects in the bulk of protein crystals, but the lack of sufficient contrast is frequently a limiting factor. We experimentally demonstrate that this barrier can be circumvented using a method that combines phase sensitive and diffraction imaging principles. Details of defects revealed in tetragonal lysozyme and cubic ferritin crystals are presented and discussed. The approach enabling the detection of the phase changes of diffracted x rays should prove to be useful in the study of defect structures in a broad range of biological macromolecular crystals.
Document ID
20040088748
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hu, Z. W.
(NASA Marshall Space Flight Center Huntsville AL United States)
Lai, B.
Chu, Y. S.
Cai, Z.
Mancini, D. C.
Thomas, B. R.
Chernov, A. A.
Date Acquired
August 21, 2013
Publication Date
October 1, 2001
Publication Information
Publication: Physical review letters
Volume: 87
Issue: 14
ISSN: 0031-9007
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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