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Effect of spaceflight on the maximal shortening velocity, morphology, and enzyme profile of fast- and slow-twitch skeletal muscle fibers in rhesus monkeysWeightlessness has been shown to cause limb muscle wasting and a reduced peak force and power in the antigravity soleus muscle. Despite a reduced peak power, Caiozzo et al. observed an increased maximal shortening velocity in the rat soleus muscle following a 14-day space flight. The major purpose of the present investigation was to determine if weightlessness induced an elevated velocity in the antigravity slow type I fibers of the rhesus monkey (Macaca mulatta), as well as to establish a cellular mechanism for the effect. Spaceflight or models of weightlessness have been shown to increase glucose uptake, elevate muscle glycogen content, and increase fatigability of the soleus muscle. The latter appears to be in part caused by a reduced ability of the slow oxidative fibers to oxidize fats. A second goal of this study was to establish the extent to which weightlessness altered the substrate profile and glycolytic and oxidative enzyme capacity of individual slow- and fast-twitch fibers.
Document ID
20040088844
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Fitts, R. H.
(Marquette University Milwaukee, WI, United States)
Romatowski, J. G.
De La Cruz, L.
Widrick, J. J.
Desplanches, D.
Date Acquired
August 21, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 7
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Flight Experiment
Non-NASA Center
NASA Discipline Musculoskeletal
Bion 11 Project
NASA Experiment Number 8913020 2/2
short duration
unmanned

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