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Sleep and respiration in microgravitySleep studies conducted during the STS-90 Neurolab mission are explored. The relationship between sleep, melatonin, and circadian phase is reviewed. The study contained both sleep and awake components. The objectives of the sleep component were to test five hypotheses: that circadian rhythms of core body temperature and urinary melatonin are synchronized to required sleep-wake schedules, that spaceflight results in substantial disruption of sleep, that the pattern of chest and abdominal wall motion alters during the different sleep stages in microgravity, that arterial oxygen saturation is reduced during some stages of sleep in microgravity, and that pre-sleep administration of melatonin during microgravity results in improved sleep quality. The awake component tested three hypotheses: that ventilatory response to carbon dioxide is increased during exposure to microgravity and that this exacerbates sleep disruption, that ventilatory response to hypoxia is increased by exposure to microgravity, and that the improved sleep resulting from the pre-sleep administration of melatonin enhances next day cognition when compared to placebo.
Document ID
20040088884
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Prisk, G. K.
(University of California San Diego, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 1998
Publication Information
Publication: Neuroscience news
Volume: 5
Issue: 1
ISSN: 1027-6599
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Flight Experiment
short duration
NASA Discipline Cardiopulmonary
STS-90 Shuttle Project
NASA Experiment Number 9301198
manned

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