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Analysis of mutant quantity and quality in human-hamster hybrid AL and AL-179 cells exposed to 137Cs-gamma or HZE-Fe ionsWe measured the number of mutants and the kinds of mutations induced by 137Cs-gamma and by HZE-Fe (56Fe [600 MeV/amu, LET = 190 KeV/micrometer) in standard AL human hamster hybrid cells and in a new variant hybrid, AL-179. We found that HZE-Fe was more mutagenic than 137Cs-gamma per unit dose (about 1.6 fold), but was slightly less mutagenic per mean lethal dose, DO, at both the S1 and hprt- loci of AL cells. On the other hand, HZE-Fe induced about nine fold more complex S1- mutants than 137Cs-gamma rays, 28% vs 3%. 137Cs-gamma rays induced about twice as many S1- mutants and hprt-mutants in AL-179 as in AL cells, and about nine times more of the former were complex, and potentially unstable kinds of mutations.
Document ID
20040088948
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Waldren, C.
(Colorado State University Fort Collins 80523, United States)
Vannais, D.
Drabek, R.
Gustafson, D.
Kraemer, S.
Lenarczyk, M.
Kronenberg, A.
Hei, T.
Ueno, A.
Chatterjee, A.
Date Acquired
August 21, 2013
Publication Date
January 1, 1998
Publication Information
Publication: Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Volume: 22
Issue: 4
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG0-232
CONTRACT_GRANT: CA36447
CONTRACT_GRANT: May-92
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center

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