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Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerizationHexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonensymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5'-phosphoro-2-methyl imidazolides.
Document ID
20040089019
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Kozlov, I. A.
(The Salk Institute for Biological Studies San Diego, California 92186, United States)
De Bouvere, B.
Van Aerschot, A.
Herdewijn, P.
Orgel, L. E.
Date Acquired
August 21, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Journal of the American Chemical Society
Volume: 121
Issue: 25
ISSN: 0002-7863
Subject Category
Exobiology
Funding Number(s)
CONTRACT_GRANT: NAG5-4118
CONTRACT_GRANT: GOA 97
CONTRACT_GRANT: NAG5-4546
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology

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