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In vitro evolution of nucleic acidsThe author reviews recent published reports of in vitro selection and evolution of nucleic acids. These nucleic acids will bind to a target ligand or catalyze a specific chemical reaction. The terms aptamers and systematic evolution of ligands by exponential enrichment (SELEX) are explained. The review focuses on protein binders, small molecule binders, and ribozymes obtained by directed evolution. The reference list identifies articles of special or outstanding interest.
Document ID
20040089662
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Joyce, G. F.
(The Scripps Research Institute La Jolla, United States)
Miller, S. L.
Date Acquired
August 21, 2013
Publication Date
January 1, 1994
Publication Information
Publication: Current opinion in structural biology
Volume: 4
ISSN: 0959-440X
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
Review Literature
NASA Discipline Exobiology

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