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Mechanisms of post-flight orthostatic intolerancePost-flight orthostatic intolerance is a dramatic physiological consequence of human adaptation to microgravity made inappropriate by a sudden return to 1-G. The immediate mechanism is almost always a failure to maintain adequate tissue perfusion, specifically perfusion of the central nervous system, but vestibular dysfunction may occasionally be the primary cause. Orthostatic intolerance is present in a wide range of clinical disorders of the nervous and cardiovascular systems. The intolerance that is produced by spaceflight and 1-G analogs (bed rest, head-down tilt at a moderate angle, water immersion) is different from its clinical counterparts by being only transiently present in subjects who otherwise have normal cardiovascular and regulatory systems. However, the same set of basic pathophysiological elements should be considered in the analysis of any form of orthostatic intolerance.
Document ID
20040089965
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Blomqvist, C. G.
(University of Texas Southwestern Medical Center Dallas, Texas, United States)
Buckey, J. C.
Gaffney, F. A.
Lane, L. D.
Levine, B. D.
Watenpaugh, D. E.
Date Acquired
August 21, 2013
Publication Date
May 1, 1994
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 1
Issue: 1
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAS9-16044
CONTRACT_GRANT: NAS9-18139
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary
STS-40 Shuttle Project
NASA Discipline Number 00-00
short duration
STS-55 Shuttle Project
NASA Program Flight
manned
Flight Experiment

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