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Collagen in organ developmentIt is important to know whether microgravity will adversely affect developmental processes. Collagens are macromolecular structural components of the extracellular matrix (ECM) which may be altered by perturbations in gravity. Interstitial collagens have been shown to be necessary for normal growth and morphogenesis in some embryonic organs, and in the mouse salivary gland, the biosynthetic pattern of these molecules changes during development. Determination of the effects of microgravity on epithelial organ development must be preceded by crucial ground-based studies. These will define control of normal synthesis, secretion, and deposition of ECM macromolecules and the relationship of these processes to morphogenesis.
Document ID
20040090244
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Hardman, P.
(Kansas State University Manhattan 66506-4901, United States)
Spooner, B. S.
Date Acquired
August 21, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Transactions of the Kansas Academy of Science
Volume: 95
Issue: 2-Jan
ISSN: 0022-8443
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAGW-2328
CONTRACT_GRANT: NAGW-1197
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
NASA Discipline Developmental Biology
NASA Program NSCORT
NASA Discipline Number 93-10
Non-NASA Center

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