NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Effect of oral calcium and calcium + fluoride treatments on mouse bone properties during suspensionThe bone effects of oral dosages of calcium chloride with or without supplementary sodium fluoride were assessed in antiorthostatically suspended mice. Two calcium dosages were used to replace half (3.1 mM) or all(6.3 mM) of the dietary calcium lost due to reduced food intake by the suspended mice. Two groups of 6.3 mM CaCl2-treated mice were additionally treated with 0.25 or 2.5 mM NaF. The results indicate that supplementation of the mouse drinking water with calcium salts prevents bone changes induced by short-term suspension, while calcium salts in combination with fluoride are less effective as fluoride dosage increases. However, the calcium supplements change the relationship between the femur mechanical properties and the mineral composition of the bone. Because of this, it appears that oral calcium supplements are effective through a mechanism other than simple dietary supplementation and may indicate a dependence of bone consistency on systemic and local fluid conditions.
Document ID
20040090259
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Simske, S. J.
(University of Colorado Boulder 80309-0429)
Luttges, M. W.
Allen, K. A.
Spooner, B. S.
Date Acquired
August 21, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Biomimetics
Volume: 1
Issue: 4
ISSN: 1059-0153
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAGW-1197
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Number 93-10
NASA Discipline Developmental Biology
NASA Discipline Cell Biology
NASA Program NSCORT

Available Downloads

There are no available downloads for this record.
No Preview Available