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Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiationThe biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represent a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space.
Document ID
20040090400
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nelson, G. A.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena CA United States)
Schubert, W. W.
Marshall, T. M.
Date Acquired
August 21, 2013
Publication Date
January 1, 1992
Publication Information
Publication: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements
Volume: 20
Issue: 1
ISSN: 0735-245X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
short duration
NASA Program Flight
NASA Center JPL
NASA Discipline Radiation Health
NASA Experiment Number 284050 1/1
NASA Program Radiation Health
manned
Flight Experiment
NASA Discipline Number 04-10
NASA Discipline Number 00-00
STS-42 Shuttle Project

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