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Evolution of catalytic functionAn RNA-based evolution system was constructed in the laboratory and used to develop RNA enzymes with novel catalytic function. By controlling the nature of the catalytic task that the molecules must perform in order to survive, it is possible to direct the evolving population toward the expression of some desired catalytic behavior. More recently, this system has been coupled to an in vitro translation procedure, raising the possibility of evolving protein enzymes in the laboratory to produce novel proteins with desired catalytic properties. The aim of this line of research is to reduce darwinian evolution, the fundamental process of biology, to a laboratory procedure that can be made to operate in the service of organic synthesis.
Document ID
20040090425
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Joyce, G. F.
(The Scripps Research Institute La Jolla, California 92037)
Date Acquired
August 21, 2013
Publication Date
June 1, 1993
Publication Information
Publication: Pure and applied chemistry. Chimie pure et appliquee
Volume: 65
Issue: 6
ISSN: 0033-4545
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Exobiology
Non-NASA Center
NASA Discipline Exobiology
NASA Discipline Number 52-20

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