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Genomic clocks and evolutionary timescalesFor decades, molecular clocks have helped to illuminate the evolutionary timescale of life, but now genomic data pose a challenge for time estimation methods. It is unclear how to integrate data from many genes, each potentially evolving under a different model of substitution and at a different rate. Current methods can be grouped by the way the data are handled (genes considered separately or combined into a 'supergene') and the way gene-specific rate models are applied (global versus local clock). There are advantages and disadvantages to each of these approaches, and the optimal method has not yet emerged. Fortunately, time estimates inferred using many genes or proteins have greater precision and appear to be robust to different approaches.
Document ID
20040101386
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Blair Hedges, S.
(NASA Headquarters Washington, DC United States)
Kumar, Sudhir
Date Acquired
August 21, 2013
Publication Date
April 1, 2003
Publication Information
Publication: Trends in genetics : TIG
Volume: 19
Issue: 4
ISSN: 0168-9525
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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