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A simple method for quantitating the propensity for calcium oxalate crystallization in urineTo assess the propensity for spontaneous crystallization of calcium oxalate in urine, the permissible increment in oxalate is calculated. The previous method required visual observation of crystallization with the addition of oxalate, this warranted the need for a large volume of urine and a sacrifice in accuracy in defining differences between small incremental changes of added oxalate. Therefore, this method has been miniaturized and spontaneous crystallization is detected from the depletion of radioactive oxalate. The new "micro" method demonstrated a marked decrease (p < 0.001) in the permissible increment in oxalate in urine of stone formers versus normal subjects. Moreover, crystallization inhibitors added to urine, in vitro (heparin or diphosphonate) or in vivo (potassium citrate administration), substantially increased the permissible increment in oxalate. Thus, the "micro" method has proven reliable and accurate in discriminating stone forming from control urine and in distinguishing changes of inhibitory activity.
Document ID
20040112170
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wabner, C. L.
(University of Texas, Southwestern Medical Center at Dallas United States)
Pak, C. Y.
Date Acquired
August 21, 2013
Publication Date
July 1, 1991
Publication Information
Publication: The Journal of lithotripsy & stone disease
Volume: 3
Issue: 3
ISSN: 1040-2152
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: MO1-RR00633
CONTRACT_GRANT: RO1-AR16061
CONTRACT_GRANT: PO1-DK20543
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
NASA Discipline Number 18-10
NASA Program Biomedicine
Non-NASA Center

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