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Similarity of urinary risk factors among stone-forming patients in five regions of the United StatesStudy Objective: To compare urinary biochemical risk factors among stone-forming patients in the Southeast (SE) or "stone belt" versus four other regions of the United States. Design: Prospective biochemical survey for regional comparisons. Setting: Referral-based nephrolithiasis clinics, urologists, nephrologists, and family practitioners. Patients: Consecutive sample of 3473 stone-forming patients who submitted 24-hour urine collections for biochemical analyses of stone-forming risk factors. Interventions: None. Subjects taking medication known to interfere with stone-forming risk factors were deleted from the final data compilation. Measurements and Main Results: Overall, the mean values for each urinary parameter spanned a narrow range without significant difference between the five regions. Among "metabolic" factors, 40% in the SE had hypercalciuria (> 6.25 mmol/d), compared to 35%-43% in other regions, and hyperuricosuria (> 4.2 mmol/d) was found in 16% in the SE versus 17%-19% elsewhere. Among "environmental" factors, low urine volume ( < 2 L/d) was found in 77% patients in the SE compared to 69%-78% elsewhere, and high sodium was encountered in 27% in the SE versus 24%-29% elsewhere. No differences were noted in occurrence of other abnormal risk factors: hyperoxaluria, hypocitraturia, low pH, high sulfate, high phosphorus, or low magnesium. Conclusions: Despite expected regional differences in nutritional and environmental influences, the results of this study showed a striking similarity in urinary biochemical risk factor profiles of stone-formers in all five regions of the United States.
Document ID
20040112172
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Harvey, J. A.
(University of Texas, Southwestern Medical Center Dallas, United States)
Hill, K. D.
Pak, C. Y.
Date Acquired
August 21, 2013
Publication Date
April 1, 1990
Publication Information
Publication: The Journal of lithotripsy & stone disease
Volume: 2
Issue: 2
ISSN: 1040-2152
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: M01-RR00633
CONTRACT_GRANT: P01-DK20543
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 18-10
NASA Program Biomedicine
NASA Discipline Regulatory Physiology
Non-NASA Center

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