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Multiple subclasses of Purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflexThe neural "learning rules" governing the induction of plasticity in the cerebellum were analyzed by recording the patterns of neural activity in awake, behaving animals during stimuli that induce a form of cerebellum-dependent learning. We recorded the simple- and complex-spike responses of a broad sample of Purkinje cells in the floccular complex during a number of stimulus conditions that induce motor learning in the vestibulo-ocular reflex (VOR). Each subclass of Purkinje cells carried essentially the same information about required changes in the gain of the VOR. The correlation of simple-spike activity in Purkinje cells with activity in vestibular pathways could guide learning during low-frequency but not high-frequency stimuli. Climbing fiber activity could guide learning during all stimuli tested but only if compared with the activity present approximately 100 msec earlier in either vestibular pathways or Purkinje cells.
Document ID
20040112175
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Raymond, J. L.
(University of California San Francisco 94143, United States)
Lisberger, S. G.
Date Acquired
August 21, 2013
Publication Date
March 1, 1997
Publication Information
Publication: Learning & memory (Cold Spring Harbor, N.Y.)
Volume: 3
Issue: 6
ISSN: 1072-0502
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: EY10198
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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