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NO, nitrotyrosine, and cyclic GMP in signal transductionOver the past 25 years, the role of nitric oxide (NO) in biology has evolved from being recognized as an environmental pollutant to an endogenously produced substance involved in cell communication and signal transduction. NO is produced by a family of enzymes called nitric oxide synthases (NOSs), which can be stimulated by a variety of factors that mediate responses to various stimuli. NO can initiate its biological effects through activation of the heterodimeric enzyme, soluble guanylyl cyclase (sGC), or through several other chemical reactions. Activation of sGC results in the production of 3',5'-cyclic guanosine monophosphate (cGMP), an intracellular second messenger signaling molecule, which can subsequently mediate such diverse physiological events such as vasodilatation and immunomodulation. Chemically reactive NO can affect physiological changes through modifications to cellular proteins, one of which is tyrosine nitration. The demonstration that NO is involved in so many biological pathways indicates the importance of this endogenously produced substance, and suggests that there is much more to be discovered about its role in biology in years to come.
Document ID
20040112384
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hanafy, K. A.
(Institute of Molecular Medicine, University of Texas Medical School Houston, Texas 77030, United States)
Krumenacker, J. S.
Murad, F.
Date Acquired
August 21, 2013
Publication Date
July 1, 2001
Publication Information
Publication: Medical science monitor : international medical journal of experimental and clinical research
Volume: 7
Issue: 4
ISSN: 1234-1010
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary
Review, Academic
Review

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