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Stromal cells can contribute oncogenic signalsThe majority of studies of neoplastic transformation have focused attention on events that occur within transformed cells. These cell autonomous events result in the disruption of molecular pathways that regulate basic activities of the cells such as proliferation, death, movement and genomic integrity. Other studies have addressed the microenvironment of tumor cells and documented its importance in supporting tumor progression. Recent work has begun to expand on these initial studies of tumor microenvironment and now provide novel insights into the possible initiation and progression of malignant cells. This review will address the transforming effect of stromal cells on epithelial components. Copyright 2001 Academic Press.
Document ID
20040112472
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Tlsty, T. D.
(University of California San Francisco 94143-0506, United States)
Date Acquired
August 21, 2013
Publication Date
April 1, 2001
Publication Information
Publication: Seminars in cancer biology
Volume: 11
Issue: 2
ISSN: 1044-579X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
NASA Discipline Radiation Health
Review, Tutorial

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