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Stimulus-response incompatibility activates cortex proximate to three eye fieldsWe used functional magnetic resonance imaging (fMRI) to investigate cortical activation during the performance of three oculomotor tasks that impose increasing levels of cognitive demand. (1) In a visually guided saccade (VGS) task, subjects made saccades to flashed targets. (2) In a compatible task, subjects made leftward and rightward saccades in response to foveal presentation of the uppercase words "LEFT" or "RIGHT." (3) In a mixed task, subjects made rightward saccades in response to the lowercase word "left" and leftward saccades in response to the lowercase word "right" on incompatible trials (60%). The remaining 40% of trials required compatible responses to uppercase words. The VGS and compatible tasks, when compared to fixation, activated the three cortical eye fields: the supplementary eye field (SEF), the frontal eye field (FEF), and the parietal eye field (PEF). The mixed task, when compared to the compatible task, activated three additional cortical regions proximate to the three eye fields: (1) rostral to the SEF in medial frontal cortex; (2) rostral to the FEF in dorsolateral prefrontal cortex (DLPFC); (3) rostral and lateral to the PEF in posterior parietal cortex. These areas may contribute to the suppression of prepotent responses and in holding novel visuomotor associations in working memory. Copyright 2001 Academic Press.
Document ID
20040112482
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Merriam, E. P.
(University of Pittsburgh Pittsburgh, Pennsylvania 15213, United States)
Colby, C. L.
Thulborn, K. R.
Luna, B.
Olson, C. R.
Sweeney, J. A.
Date Acquired
August 21, 2013
Publication Date
May 1, 2001
Publication Information
Publication: NeuroImage
Volume: 13
Issue: 5
ISSN: 1053-8119
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: MH45156
CONTRACT_GRANT: NS35949
CONTRACT_GRANT: MH01433
CONTRACT_GRANT: MH42969
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Neuroscience
Non-NASA Center

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