NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Mitral inertance in humans: critical factor in Doppler estimation of transvalvular pressure gradientsThe pressure-velocity relationship across the normal mitral valve is approximated by the Bernoulli equation DeltaP = 1/2 rhoDeltav(2) + M. dv/dt, where DeltaP is the atrioventricular pressure difference, rho is blood density, v is transmitral flow velocity, and M is mitral inertance. Although M is indispensable in assessing transvalvular pressure differences from transmitral flow, this term is poorly understood. We measured intraoperative high-fidelity left atrial and ventricular pressures and simultaneous transmitral flow velocities by using transesophageal echocardiography in 100 beats (8 patients). We computed mean mitral inertance (M) by M = integral((DeltaP)-(1/2 x rho v(2))dt/integral(dv/dt)dt and we assessed the effect of the inertial term on the transmitral pressure-flow relation. ranged from 1.03 to 5.96 g/cm(2) (mean = 3.82 +/- 1.22 g/cm(2)). DeltaP calculated from the simplified Bernoulli equation (DeltaP = 1/2. rhov(2)) lagged behind (44 +/- 11 ms) and underestimated the actual peak pressures (2.3 +/- 1.1 mmHg). correlated with left ventricular systolic pressure (r = -0.68, P < 0.0001) and transmitral pressure gradients (r = 0.65, P < 0.0001). Because mitral inertance causes the velocity to lag significantly behind the actual pressure gradient, it needs to be considered when assessing diastolic filling and the pressure difference across normal mitral valves.
Document ID
20040112583
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nakatani, S.
(The Cleveland Clinic Foundation Cleveland, Ohio 44195)
Firstenberg, M. S.
Greenberg, N. L.
Vandervoort, P. M.
Smedira, N. G.
McCarthy, P. M.
Thomas, J. D.
Date Acquired
August 21, 2013
Publication Date
March 1, 2001
Publication Information
Publication: American journal of physiology. Heart and circulatory physiology
Volume: 280
Issue: 3
ISSN: 0363-6135
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 1R01-HL-56688
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available