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Muscle sympathetic nerve responses to physiological changes in prostaglandin production in humansPrevious studies suggest that prostaglandins may contribute to exercise-induced increases in muscle sympathetic nerve activity (MSNA). To test this hypothesis, MSNA was measured at rest and during exercise before and after oral administration of ketoprofen, a cyclooxygenase inhibitor, or placebo. Twenty-one subjects completed two bouts of graded dynamic and isometric handgrip to fatigue. Each exercise bout was followed by 2 min of postexercise muscle ischemia. The second exercise bouts were performed after 60 min of rest in which 11 subjects were given ketoprofen (300 mg) and 10 subjects received a placebo. Ketoprofen significantly lowered plasma thromboxane B(2) in the drug group (from 36 +/- 6 to 22 +/- 3 pg/ml, P < 0.04), whereas thromboxane B(2) in the placebo group increased from 40 +/- 5 to 61 +/- 9 pg/ml from trial 1 to trial 2 (P < 0.008). Ketoprofen and placebo did not change sympathetic and cardiovascular responses to dynamic handgrip, isometric handgrip, and postexercise muscle ischemia. There was no relationship between thromboxane B(2) concentrations and MSNA or arterial pressure responses during both exercise modes. The data indicate that physiological increases or decreases in prostaglandins do not alter exercise-induced increases in MSNA and arterial pressure in humans. These findings suggest that contraction-induced metabolites other than prostaglandins mediate MSNA responses to exercise in humans.
Document ID
20040112605
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Doerzbacher, K. J.
(General Clinical Research Center, Pennsylvania State University College of Medicine Hershey, Pennsylvania 17033, United States)
Ray, C. A.
Date Acquired
August 21, 2013
Publication Date
February 1, 2001
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 90
Issue: 2
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: M01 RR10732
CONTRACT_GRANT: R01 HL-58503
Distribution Limits
Public
Copyright
Other
Keywords
Clinical Trial
Non-NASA Center
NASA Program Biomedical Research and Countermeasures
Randomized Controlled Trial
NASA Discipline Neuroscience

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