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Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studiesOBJECTIVES: To validate the accuracy of real-time three-dimensional echocardiography (RT3DE) for quantifying aneurysmal left ventricular (LV) volumes. BACKGROUND: Conventional two-dimensional echocardiography (2DE) has limitations when applied for quantification of LV volumes in patients with LV aneurysms. METHODS: Seven aneurysmal balloons, 15 sheep (5 with chronic LV aneurysms and 10 without LV aneurysms) during 60 different hemodynamic conditions and 29 patients (13 with chronic LV aneurysms and 16 with normal LV) underwent RT3DE and 2DE. Electromagnetic flow meters and magnetic resonance imaging (MRI) served as reference standards in the animals and in the patients, respectively. Rotated apical six-plane method with multiplanar Simpson's rule and apical biplane Simpson's rule were used to determine LV volumes by RT3DE and 2DE, respectively. RESULTS: Both RT3DE and 2DE correlated well with actual volumes for aneurysmal balloons. However, a significantly smaller mean difference (MD) was found between RT3DE and actual volumes (-7 ml for RT3DE vs. 22 ml for 2DE, p = 0.0002). Excellent correlation and agreement between RT3DE and electromagnetic flow meters for LV stroke volumes for animals with aneurysms were observed, while 2DE showed lesser correlation and agreement (r = 0.97, MD = -1.0 ml vs. r = 0.76, MD = 4.4 ml). In patients with LV aneurysms, better correlation and agreement between RT3DE and MRI for LV volumes were obtained (r = 0.99, MD = -28 ml) than between 2DE and MRI (r = 0.91, MD = -49 ml). CONCLUSIONS: For geometrically asymmetric LVs associated with ventricular aneurysms, RT3DE can accurately quantify LV volumes.
Document ID
20040141404
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Qin, J. X.
(the Cleveland Clinic Foundation Ohio 44195, United States)
Jones, M.
Shiota, T.
Greenberg, N. L.
Tsujino, H.
Firstenberg, M. S.
Gupta, P. C.
Zetts, A. D.
Xu, Y.
Ping Sun, J.
Cardon, L. A.
Odabashian, J. A.
Flamm, S. D.
White, R. D.
Panza, J. A.
Thomas, J. D.
Date Acquired
August 22, 2013
Publication Date
September 1, 2000
Publication Information
Publication: Journal of the American College of Cardiology
Volume: 36
Issue: 3
ISSN: 0735-1097
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: ROI-HL 56688-01A1
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

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