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Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold-Jarisch reflexThe aim of this study was to determine whether 5-hydroxytryptamine (5-HT)(3) receptors on cardiopulmonary afferents mediating the Bezold-Jarisch reflex (BJR) desensitize upon repeated exposure to selective agonists. BJR-mediated falls in heart rate, diastolic arterial blood pressure and cardiac output elicited by the 5-HT(3)-receptor agonists, phenylbiguanide (100 microg/kg, i.v.) or 2-methyl-5-HT (100 microg/kg, i.v.), progressively diminished upon repeated injection in conscious rats. The BJR responses elicited by 5-HT (40 microg/kg, i.v.) were markedly reduced in rats which had received the above injections of phenylbiguanide or 2-methyl-5-HT whereas the BJR responses elicited by L-S-nitrosocysteine (10 micromol/kg, i.v.) were similar before and after the injections of the 5-HT(3) receptor agonists. These findings suggest that tachyphylaxis to 5-HT(3) receptor agonists may be due to the desensitization of 5-HT(3) receptors on cardiopulmonary afferents rather than the impairment of the central or peripheral processing of the BJR.
Document ID
20040141455
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Whalen, E. J.
(The University of Iowa Iowa City, IA 52242, United States)
Johnson, A. K.
Lewis, S. J.
Date Acquired
August 22, 2013
Publication Date
August 11, 2000
Publication Information
Publication: Brain research
Volume: 873
Issue: 2
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL14388
CONTRACT_GRANT: HL57472
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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