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Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individualsThe purposes of the present studies were to test the hypotheses that lower dosages of oral pyruvate ingestion would increase blood pyruvate concentration and that the ingestion of a commonly recommended dosage of pyruvate (7 g) for 7 days would enhance performance during intense aerobic exercise in well-trained individuals. Nine recreationally active subjects (8 women, 1 man) consumed 7, 15, and 25 g of pyruvate and were monitored for a 4-h period to determine whether blood metabolites were altered. Pyruvate consumption failed to significantly elevate blood pyruvate, and it had no effect on indexes of carbohydrate (blood glucose, lactate) or lipid metabolism (blood glycerol, plasma free fatty acids). As a follow-up, we administered 7 g/day of either placebo or pyruvate, for a 1-wk period to seven, well-trained male cyclists (maximal oxygen consumption, 62.3 +/- 3.0 ml. kg(-1). min(-1)) in a randomized, double-blind, crossover trial. Subjects cycled at 74-80% of their maximal oxygen consumption until exhaustion. There was no difference in performance times between the two trials (placebo, 91 +/- 9 min; pyruvate, 88 +/- 8 min). Measured blood parameters (insulin, peptide C, glucose, lactate, glycerol, free fatty acids) were also unaffected. Our results indicate that oral pyruvate supplementation does not increase blood pyruvate content and does not enhance performance during intense exercise in well-trained cyclists.
Document ID
20040141460
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Morrison, M. A.
(University of Guelph Ontario, Canada)
Spriet, L. L.
Dyck, D. J.
Date Acquired
August 22, 2013
Publication Date
August 1, 2000
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 89
Issue: 2
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Randomized Controlled Trial
NASA Discipline Musculoskeletal
Non-NASA Center
Controlled Clinical Trial
Clinical Trial

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