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Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinaseMyotonic dystrophy protein kinase (DMPK) is a serine-threonine protein kinase encoded by the myotonic dystrophy (DM) locus on human chromosome 19q13.3. It is a close relative of other kinases that interact with members of the Rho family of small GTPases. We show here that the actin cytoskeleton-linked GTPase Rac-1 binds to DMPK, and coexpression of Rac-1 and DMPK activates its transphosphorylation activity in a GTP-sensitive manner. DMPK can also bind Raf-1 kinase, the Ras-activated molecule of the MAP kinase pathway. Purified Raf-1 kinase phosphorylates and activates DMPK. The interaction of DMPK with these distinct signals suggests that it may play a role as a nexus for cross-talk between their respective pathways and may partially explain the remarkable pleiotropy of DM.
Document ID
20040141499
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Shimizu, M.
(Baylor College of Medicine One Baylor Plaza, Houston, TX 77030, United States)
Wang, W.
Walch, E. T.
Dunne, P. W.
Epstein, H. F.
Date Acquired
August 22, 2013
Publication Date
June 23, 2000
Publication Information
Publication: FEBS letters
Volume: 475
Issue: 3
ISSN: 0014-5793
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
NASA Program Biomedical Research and Countermeasures
Non-NASA Center

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