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Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotidesOligonucleotide 5'-polyphosphates are formed under potentially prebiotic conditions from oligonucleotide 5'-phosphates and sodium trimetaphosphate. Oligonucleotides activated as polyphosphates undergo template-directed ligation. We believe that these reactions could have produced longer oligonucleotide products from shorter substrates under prebiotic conditions.
Document ID
20040141545
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
doi:10.1023/A:1006683507864
Authors
Gao, K. (The Salk Institute for Biological Studies San Diego, CA 92186-5800, United States)
Orgel, L. E.
Bada, J. L.
Date Acquired
August 22, 2013
Publication Date
February 1, 2000
Publication Information
Publication: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
Volume: 30
Issue: 1
ISSN: 0169-6149
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center

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