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The potential influence of radiation-induced microenvironments in neoplastic progressionIonizing radiation is a complete carcinogen, able both to initiate and promote neoplastic progression and is a known carcinogen of human and murine mammary gland. Tissue response to radiation is a composite of genetic damage, cell death and induction of new gene expression patterns. Although DNA damage is believed to initiate carcinogenesis, the contribution of these other aspects of radiation response are beginning to be explored. Our studies demonstrate that radiation elicits rapid and persistent global alterations in the mammary gland microenvironment. We postulate that radiation-induced microenvironments may affect epithelial cells neoplastic transformation by altering their number or susceptibility. Alternatively, radiation induced microenvironments may exert a selective force on initiated cells and/or be conducive to progression. A key impetus for these studies is the possibility that blocking these events could be a strategy to interrupt neoplastic progression.
Document ID
20040141559
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Barcellos-Hoff, M. H.
(Lawrence Berkeley National Laboratory Berkeley, California 94720, United States)
Chatterjee, A.
Date Acquired
August 22, 2013
Publication Date
April 1, 1998
Publication Information
Publication: Journal of mammary gland biology and neoplasia
Volume: 3
Issue: 2
ISSN: 1083-3021
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA-51841
Distribution Limits
Public
Copyright
Other
Keywords
Review, Academic
NASA Discipline Radiation Health
Review
Non-NASA Center

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