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atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brainDrosophila atonal (ato) is the proneural gene of the chordotonal organs (CHOs) in the peripheral nervous system (PNS) and the larval and adult photoreceptor organs. Here, we show that ato is expressed at multiple stages during the development of a lineage of central brain neurons that innervate the optic lobes and are required for eclosion. A novel fate mapping approach shows that ato is expressed in the embryonic precursors of these neurons and that its expression is reactivated in third instar larvae (L3). In contrast to its function in the PNS, ato does not act as a proneural gene in the embryonic brain. Instead, ato performs a novel function, regulating arborization during larval and pupal development by interacting with Notch.
Document ID
20040141599
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hassan, B. A.
(Howard Hughes Medical Institute, Baylor College of Medicine Department of Human and Molecular Genetics, Houston, Texas 77030, United States)
Bermingham, N. A.
He, Y.
Sun, Y.
Jan, Y. N.
Zoghbi, H. Y.
Bellen, H. J.
Date Acquired
August 22, 2013
Publication Date
March 1, 2000
Publication Information
Publication: Neuron
Volume: 25
Issue: 3
ISSN: 0896-6273
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Developmental Biology
Non-NASA Center

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