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Primate translational vestibuloocular reflexes. III. Effects of bilateral labyrinthine electrical stimulationThe effects of functional, reversible ablation and potential recruitment of the most irregular otolith afferents on the dynamics and sensitivity of the translational vestibuloocular reflexes (trVORs) were investigated in rhesus monkeys trained to fixate near and far targets. Translational motion stimuli consisted of either steady-state lateral and fore-aft sinusoidal oscillations or short-lasting transient lateral head displacements. Short-duration (usually <2 s) anodal (inhibitory) and cathodal (excitatory) currents (50-100 microA) were delivered bilaterally during motion. In the presence of anodal labyrinthine stimulation, trVOR sensitivity and its dependence on viewing distance were significantly decreased. In addition, anodal currents significantly increased phase lags. During transient motion, anodal stimulation resulted in significantly lower initial eye acceleration and more sluggish responses. Cathodal currents tended to have opposite effects. The main characteristics of these results were simulated by a simple model where both regularly and irregularly discharging afferents contribute to the trVORs. Anodal labyrinthine currents also were found to decrease eye velocity during long-duration, constant velocity rotations, although results were generally more variable compared with those during translational motion.
Document ID
20040141637
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Angelaki, D. E.
(University of Mississippi Medical Center Jackson, Mississippi 39216-4505, United States)
McHenry, M. Q.
Dickman, J. D.
Perachio, A. A.
Date Acquired
August 22, 2013
Publication Date
March 1, 2000
Publication Information
Publication: Journal of neurophysiology
Volume: 83
Issue: 3
ISSN: 0022-3077
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: EY-12814
CONTRACT_GRANT: EY-10851
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research and Countermeasures
NASA Discipline Neuroscience
Non-NASA Center

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