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Nitric oxide donors, sodium nitroprusside and S-nitroso-N-acetylpencillamine, stimulate myoblast proliferation in vitroNitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 microM) of donor concentrations. However, 50 microM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 microM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation.
Document ID
20040141839
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ulibarri, J. A.
(University of Wisconsin Medical School Madison 53711, United States)
Mozdziak, P. E.
Schultz, E.
Cook, C.
Best, T. M.
Date Acquired
August 22, 2013
Publication Date
April 1, 1999
Publication Information
Publication: In vitro cellular & developmental biology. Animal
Volume: 35
Issue: 4
ISSN: 1071-2690
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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