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Development of a flow feedback pulse duplicator system with rhesus monkey arterial input impedance characteristicsAn in vitro pulsatile pump flow system that is capable of producing physiologic pressures and flows in a mock circulatory system tuned to reproduce the first nine harmonics of the input impedance of a rhesus monkey was developed and tested. The system was created as a research tool for evaluating cardiovascular function and for the design, testing, and evaluation of electrical-mechanical cardiovascular models and chronically implanted sensors. The system possesses a computerized user interface for controlling a linear displacement pulsatile pump in a controlled flow loop format to emulate in vivo cardiovascular characteristics. Evaluation of the pump system consisted of comparing its aortic pressure and flow profiles with in vivo rhesus hemodynamic waveforms in the time and frequency domains. Comparison of aortic pressure and flow data between the pump system and in vivo data showed good agreement in the time and frequency domains, however, the pump system produced a larger pulse pressure. The pump system can be used for comparing cardiovascular parameters with predicted cardiovascular model values and for evaluating such items as vascular grafts, heart valves, biomaterials, and sensors. This article describes the development and evaluation of this feedback controlled cardiovascular dynamics simulation modeling system.
Document ID
20040141862
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Schaub, J. D.
(University of Texas at Austin United States)
Koenig, S. C.
Schroeder, M. J.
Ewert, D. L.
Drew, G. A.
Swope, R. D.
Convertino, V. A.
Date Acquired
August 22, 2013
Publication Date
July 1, 1999
Publication Information
Publication: ASAIO journal (American Society for Artificial Internal Organs : 1992)
Volume: 45
Issue: 4
ISSN: 1058-2916
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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