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Molecular evidence of simian virus 40 infections in childrenRecent studies have detected simian virus 40 (SV40) DNA in certain human tumors and normal tissues. The significance of human infections by SV40, which was first discovered as a contaminant of poliovirus vaccines used between 1955 and 1963, remains unknown. The occurrence of SV40 infections in unselected hospitalized children was evaluated. Polymerase chain reaction and DNA sequence analyses were done on archival tissue specimens from patients positive for SV40 neutralizing antibody. SV40 DNA was identified in samples from 4 of 20 children (1 Wilms' tumor, 3 transplanted kidney samples). Sequence variation among SV40 regulatory regions ruled out laboratory contamination of specimens. This study shows the presence of SV40 infections in pediatric patients born after 1982.
Document ID
20040141869
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Butel, J. S.
(Baylor College of Medicine Houston, Texas 77030, United States)
Arrington, A. S.
Wong, C.
Lednicky, J. A.
Finegold, M. J.
Date Acquired
August 22, 2013
Publication Date
September 1, 1999
Publication Information
Publication: The Journal of infectious diseases
Volume: 180
Issue: 3
ISSN: 0022-1899
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AI-36211
CONTRACT_GRANT: AI-07483
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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