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Mathematical model to estimate risk of calcium-containing renal stonesBACKGROUND/AIMS: Astronauts exposed to microgravity during the course of spaceflight undergo physiologic changes that alter the urinary environment so as to increase the risk of renal stone formation. This study was undertaken to identify a simple method with which to evaluate the potential risk of renal stone development during spaceflight. METHOD: We used a large database of urinary risk factors obtained from 323 astronauts before and after spaceflight to generate a mathematical model with which to predict the urinary supersaturation of calcium stone forming salts. RESULT: This model, which involves the fewest possible analytical variables (urinary calcium, citrate, oxalate, phosphorus, and total volume), reliably and accurately predicted the urinary supersaturation of the calcium stone forming salts when compared to results obtained from a group of 6 astronauts who collected urine during flight. CONCLUSIONS: The use of this model will simplify both routine medical monitoring during spaceflight as well as the evaluation of countermeasures designed to minimize renal stone development. This model also can be used for Earth-based applications in which access to analytical resources is limited.
Document ID
20040141872
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Pietrzyk, R. A.
(Wyle Life Sciences Houston, Tex., United States)
Feiveson, A. H.
Whitson, P. A.
Date Acquired
August 22, 2013
Publication Date
May 1, 1999
Publication Information
Publication: Mineral and electrolyte metabolism
Volume: 25
Issue: 3
ISSN: 0378-0392
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
Flight Experiment
short duration
manned
NASA Discipline Regulatory Physiology
STS Shuttle Project

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