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Pathophysiological basis of orthostatic hypotension in autonomic failureIn patients with autonomic failure orthostatic hypotension results from an impaired capacity to increase vascular resistance during standing. This fundamental defect leads to increased downward pooling of venous blood and a consequent reduction in stroke volume and cardiac output that exaggerates the orthostatic fall in blood pressure. The location of excessive venous blood pooling has not been established so far, but present data suggest that the abdominal compartment and perhaps leg skin vasculature are the most likely candidates. To improve the orthostatic tolerance in patients with autonomic failure, protective measures that reduce excessive orthostatic blood pooling have been developed and evaluated. These measures include physical counter-manoeuvres and abdominal compression.
Document ID
20040141877
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Smit, A. A.
(University of Amsterdam Amsterdam, The Netherlands)
Halliwill, J. R.
Low, P. A.
Wieling, W.
Date Acquired
August 22, 2013
Publication Date
August 15, 1999
Publication Information
Publication: The Journal of physiology
Volume: 519 Pt 1
ISSN: 0022-3751
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Review, Academic
Review
Non-NASA Center
NASA Discipline Cardiopulmonary

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