NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Effects of subfornical organ lesions on acutely induced thirst and salt appetiteWe examined the role of the subfornical organ (SFO) in stimulating thirst and salt appetite using two procedures that initiate water and sodium ingestion within 1-2 h of extracellular fluid depletion. The first procedure used injections of a diuretic (furosemide, 10 mg/kg sc) and a vasodilator (minoxidil, 1-3 mg/kg ia) to produce hypotension concurrently with hypovolemia. The resulting water and sodium intakes were inhibited by intravenous administration of ANG II receptor antagonist (sarthran, 8 micrograms . kg(-1). min(-1)) or angiotensin-converting enzyme inhibitor (captopril, 2.5 mg/h). The second procedure used injections of furosemide (10 mg/kg sc) and a low dose of captopril (5 mg/kg sc) to initiate water and sodium ingestion upon formation of ANG II in the brain. Electrolytic lesions of the SFO greatly reduced the water intakes, and nearly abolished the sodium intakes, produced by these relatively acute treatments. These results contrast with earlier findings showing little effect of SFO lesions on sodium ingestion after longer-term extracellular fluid depletion.
Document ID
20040141898
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Thunhorst, R. L.
(University of Iowa Iowa City, Iowa 52242-1407, United States)
Beltz, T. G.
Johnson, A. K.
Date Acquired
August 22, 2013
Publication Date
July 1, 1999
Publication Information
Publication: The American journal of physiology
Volume: 277
Issue: 1 Pt 2
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL-54292
CONTRACT_GRANT: MH-50260
CONTRACT_GRANT: HL-14388
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available