NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Brain segmentation and the generation of cortical surfacesThis paper describes methods for white matter segmentation in brain images and the generation of cortical surfaces from the segmentations. We have developed a system that allows a user to start with a brain volume, obtained by modalities such as MRI or cryosection, and constructs a complete digital representation of the cortical surface. The methodology consists of three basic components: local parametric modeling and Bayesian segmentation; surface generation and local quadratic coordinate fitting; and surface editing. Segmentations are computed by parametrically fitting known density functions to the histogram of the image using the expectation maximization algorithm [DLR77]. The parametric fits are obtained locally rather than globally over the whole volume to overcome local variations in gray levels. To represent the boundary of the gray and white matter we use triangulated meshes generated using isosurface generation algorithms [GH95]. A complete system of local parametric quadratic charts [JWM+95] is superimposed on the triangulated graph to facilitate smoothing and geodesic curve tracking. Algorithms for surface editing include extraction of the largest closed surface. Results for several macaque brains are presented comparing automated and hand surface generation. Copyright 1999 Academic Press.
Document ID
20040141960
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Joshi, M.
(Washington University St. Louis, Missouri 21218, United States)
Cui, J.
Doolittle, K.
Joshi, S.
Van Essen, D.
Wang, L.
Miller, M. I.
Date Acquired
August 22, 2013
Publication Date
May 1, 1999
Publication Information
Publication: NeuroImage
Volume: 9
Issue: 5
ISSN: 1053-8119
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: RO1-MH-52158-01A1
CONTRACT_GRANT: RO1-NS-35368
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Neuroscience
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available