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Effects of posture on blood flow diversion by hypoxic pulmonary vasoconstriction in dogsWe used differential excretion of sulphur hexafluoride from the left and right lung to measure blood flow diversion by hypoxic pulmonary vasoconstriction (HPV) in the prone and supine positions in dogs (n = 9). Gas exchange was assessed using the multiple inert gas elimination technique. Blood flow diversion from the hypoxic (3% oxygen) left lung was mean 70.7 (SD 11.2)% in the supine compared with 57.0 (12.1)% in the prone position (P < 0.02). The supine position was associated with increased perfusion to low VA/Q regions (P < 0.05). The increased flow diversion with hypoxia in the supine position was associated with more ventilation to high VA/Q regions (P < 0.05). We conclude that flow diversion by hypoxic pulmonary vasoconstriction is greater in the supine position. This effect could contribute to the variable response in gas exchange with positioning in patients with ARDS.
Document ID
20040142134
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Walther, S. M.
(University Hospital Linkoping, Sweden)
Domino, K. B.
Hlastala, M. P.
Date Acquired
August 22, 2013
Publication Date
September 1, 1998
Publication Information
Publication: British journal of anaesthesia
Volume: 81
Issue: 3
ISSN: 0007-0912
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: HL 12174
CONTRACT_GRANT: HL 24163
CONTRACT_GRANT: HL 02507
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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