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Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromasHistochemical staining for carbonic anhydrase and cholinesterase (CE) activities was used to analyze sensory and motor axon regeneration, respectively, during neuroma formation in transected and tube-encapsulated peripheral nerves. Median-ulnar and sciatic nerves in the rodent model permitted testing whether a 4 cm greater distance of the motor neuron soma from axotomy site or intrinsic differences between motor and sensory neurons influenced regeneration and neuroma formation 10, 30, and 90 days later. Ventral root radiculotomy confirmed that CE-stained axons were 97% alpha motor axons. Distance significantly delayed axon regeneration. When distance was negligible, sensory axons grew out sooner than motor axons, but motor axons regenerated to a greater quantity. These results indicate regeneration differences between axon subtypes and suggest more extensive branching of motor axons within the neuroma. Thus, both distance from injury site to soma and inherent motor and sensory differences should be considered in peripheral nerve repair strategies.
Document ID
20040142150
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Macias, M. Y.
(Medical College of Wisconsin Milwaukee 53226, United States)
Lehman, C. T.
Sanger, J. R.
Riley, D. A.
Date Acquired
August 22, 2013
Publication Date
December 1, 1998
Publication Information
Publication: Muscle & nerve
Volume: 21
Issue: 12
ISSN: 0148-639X
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: UOLNS33472-01
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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