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Deposition and dispersion of 1-micrometer aerosol boluses in the human lung: effect of micro- and hypergravityWe performed bolus inhalations of 1-micrometer particles in four subjects on the ground (1 G) and during parabolic flights both in microgravity (microG) and in approximately 1.6 G. Boluses of approximately 70 ml were inhaled at different points in an inspiration from residual volume to 1 liter above functional residual capacity. The volume of air inhaled after the bolus [the penetration volume (Vp)] ranged from 200 to 1,500 ml. Aerosol concentration and flow rate were continuously measured at the mouth. The deposition, dispersion, and position of the bolus in the expired gas were calculated from these data. For Vp >/=400 ml, both deposition and dispersion increased with Vp and were strongly gravity dependent, with the greatest deposition and dispersion occurring for the largest G level. At Vp = 800 ml, deposition and dispersion increased from 33.9% and 319 ml in microG to 56.9% and 573 ml at approximately 1.6 G, respectively (P < 0.05). At each G level, the bolus was expired at a smaller volume than Vp, and this volume became smaller with increasing Vp. Although dispersion was lower in microG than in 1 G and approximately 1.6 G, it still increased steadily with increasing Vp, showing that nongravitational ventilatory inhomogeneity is partly responsible for dispersion in the human lung.
Document ID
20040142223
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Darquenne, C.
(University of California San Diego, La Jolla, California 92093-0931, United States)
West, J. B.
Prisk, G. K.
Date Acquired
August 22, 2013
Publication Date
October 1, 1998
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 85
Issue: 4
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Parabolic Flight
manned
short duration
Non-NASA Center
NASA Discipline Cardiopulmonary
Flight Experiment

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