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Alteration of renal function of rats following spaceflightFollowing spaceflight, changes in renal function of humans have been suggested. To assess the effects of readaptation on renal function, urine was collected from male rats ( approximately 245 g) over a 2-wk period following a 14-day spaceflight. Rats were assigned to three groups: flight animals (n = 6), flight controls (n = 6) housed in the flight cages on the ground, and vivarium controls (n = 5) housed in standard shoe box cages. Animals were placed into individual metabolic cages for urine collection. Urine output was significantly increased for 3 days following flight. Excretion rates of Na+ and K+ were increased, resulting in an increased osmotic excretion rate. Creatinine excretion rate increased over the first two postflight days. Glomerular filtration rate increased immediately following spaceflight without changes in plasma creatinine, Na+, K+, or osmolality. Increased excretion of solute was thus the result of increased delivery and a decreased percent reabsorption of the filtered load. Osmolal clearance was increased immediately postflight while free water clearance was decreased. In growing rats, the diuresis after short-duration spaceflight is the result of an increase in solute excretion with an accompanying reduction in free water clearance.
Document ID
20040142228
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wade, C. E.
(NASA Ames Research Center Moffett Field CA United States)
Morey-Holton, E.
Date Acquired
August 22, 2013
Publication Date
October 1, 1998
Publication Information
Publication: The American journal of physiology
Volume: 275
Issue: 4 Pt 2
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
STS-58 Shuttle Project
short duration
manned
Flight Experiment
NASA Discipline Cardiopulmonary
NASA Center ARC

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