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Redistribution of pulmonary blood flow during unilateral hypoxia in prone and supine dogsWe used fluorescent-labeled microspheres in pentobarbital-anesthetized dogs to study the effects of unilateral alveolar hypoxia on the pulmonary blood flow distribution. The left lung was ventilated with inspired O2 fraction of 1.0, 0.09, or 0.03 in random order; the right lung was ventilated with inspired O2 fraction of 1.0. The lungs were removed, cleared of blood, dried at total lung capacity, then cubed to obtain approximately 1,500 small pieces of lung ( approximately 1.7 cm3). The coefficient of variation of flow increased (P < 0.001) in the hypoxic lung but was unchanged in the hyperoxic lung. Most (70-80%) variance in flow in the hyperoxic lung was attributable to structure, in contrast to only 30-40% of the variance in flow in the hypoxic lung (P < 0.001). When adjusted for the change in total flow to each lung, 90-95% of the variance in the hyperoxic lung was attributable to structure compared with 70-80% in the hypoxic lung (P < 0.001). The hilar-to-peripheral gradient, adjusted for change in total flow, decreased in the hypoxic lung (P = 0.005) but did not change in the hyperoxic lung. We conclude that hypoxic vasoconstriction alters the regional distribution of flow in the hypoxic, but not in the hyperoxic, lung.
Document ID
20040172669
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mann, C. M.
(University of Washington School of Medicine Seattle, Washington 98195, United States)
Domino, K. B.
Walther, S. M.
Glenny, R. W.
Polissar, N. L.
Hlastala, M. P.
Date Acquired
August 22, 2013
Publication Date
June 1, 1998
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 84
Issue: 6
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: HL-02507
CONTRACT_GRANT: HL-24163
CONTRACT_GRANT: HL-12174
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

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