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Pilot study of bone mineral density in breast cancer patients treated with adjuvant chemotherapyThe objective of this cross-sectional study was to determine lumbar spine bone mineral density (BMD) in breast cancer patients previously treated with adjuvant chemotherapy. Sixteen of 27 patients who received adjuvant chemotherapy became permanently amenorrheic as a result of chemotherapy. BMD was measured at the lumbar spine using dual energy X-ray absorptiometry (DEXA). Chemotherapy drugs and dosages along with a history of risk factors for reduced bone density including activity level, tobacco and/or alcohol use, metabolic bone disease, family history, and hormone exposure were identified. Results showed that women who became permanently amenorrheic as a result of chemotherapy had BMD 14% lower than women who maintained menses after chemotherapy. Chemotherapy-treated women who maintained ovarian function had normal BMD. This study suggests that women who have premature menopause as a result of chemotherapy for breast cancer are at increased risk of bone loss and may be at risk for early development of osteoporosis. Women who maintain menses do not appear to be at risk for accelerated trabecular bone loss.
Document ID
20040172776
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Headley, J. A.
(University of Texas Health Science Center-Houston School of Nursing, Baylor College of Medicine UT M.D. Anderson Cancer Center, United States)
Theriault, R. L.
LeBlanc, A. D.
Vassilopoulou-Sellin, R.
Hortobagyi, G. N.
Date Acquired
August 22, 2013
Publication Date
January 1, 1998
Publication Information
Publication: Cancer investigation
Volume: 16
Issue: 1
ISSN: 0735-7907
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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